Mannobioside biomimetics that trigger DC-SIGN binding selectivity

Irene Herrera-González (1) , Michel Thépaut (2) , Elena Sánchez-Fernández (1) , Antonio Di Maio (3) , Corinne Vivès (2) , Javier Rojo (4) , José García Fernández (3) , Franck Fieschi (2) , Pedro Nieto (5) , Carmen Ortiz Mellet (6)

1 Department of Organic Chemistry, Faculty of Chemistry
2 IBS - UMR 5075 - Institut de biologie structurale
3 Instituto de Investigaciones Químicas (IIQ)
4 Instituto de Investigaciones Quimicas
5 Glycosystems Laboratory, Instituto de Investigaciones Químicas
6 Universidad de Sevilla = University of Seville

Selective DC-SIGN targeting vs. langerin might lead to anti-infective agents, given their counteracting effects upon infection by some pathogens. Here we show that multivalent sp2-iminosugar-containing mannobioside analogs can achieve total DC-SIGN selectivity by levering the canonic binding mode towards high-mannose oligosaccharide ligands, behaving as factual biomimics

Domaines: Biologie structurale [q-bio.BM]

Irene Herrera-González, Michel Thépaut, Elena Sánchez-Fernández, Antonio Di Maio, Corinne Vivès, et al.. Mannobioside biomimetics that trigger DC-SIGN binding selectivity. Chemical Communications, 2022, ⟨10.1039/d2cc04478a⟩. ⟨hal-03813011⟩