Importance of Rose Bengal loaded with nanoparticles for anti-cancer photodynamic therapy

Batoul Dhaini (1) , Laurène Wagner (2) , Morgane Moinard (1) , Joël Daouk (3) , Philippe Arnoux (1) , Hervé Schohn (3) , Perrine Schneller (3) , Samir Acherar (2) , Tayssir Hamieh (4, 5) , Céline Frochot (1)

1 LRGP - Laboratoire Réactions et Génie des Procédés
2 LCPM - Laboratoire de Chimie Physique Macromoléculaire
3 CRAN - Centre de Recherche en Automatique de Nancy
4 MCEMA - Laboratoire de Matériaux, Catalyse, Environnement et Méthodes Analytiques
5 Maastricht University [Maastricht]

Rose Bengal (RB) is a photosensitizer (PS) used in anti-cancer and anti-bacterial photodynamic therapy (PDT). The specific excitation of this PS allows the production of singlet oxygen and oxygen reactive species that kill bacteria and tumor cells. In this review, we summarize the history of the use of RB as a PS coupled by chemical or physical means to nanoparticles (NPs). The studies are divided into PDT and PDT excited by X-rays (X-PDT), and subdivided on the basis of NP type. On the basis of the papers examined, it can be noted that RB used as a PS shows remarkable cytotoxicity under the effect of light, and RB loaded onto NPs is an excellent candidate for nanomedical applications in PDT and X-PDT.

Mots clés: photodynamic therapy; rose bengal; X-rays; nanomedicine; singlet oxygen; cancer; nanoparticle

Domaines: Chimie thérapeutique

Batoul Dhaini, Laurène Wagner, Morgane Moinard, Joël Daouk, Philippe Arnoux, et al.. Importance of Rose Bengal loaded with nanoparticles for anti-cancer photodynamic therapy. Pharmaceuticals, 2022, Special Issue: Photodynamic Therapy 2022, 15 (9), pp.1093. ⟨10.3390/ph15091093⟩. ⟨hal-03767594⟩