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Article Dans Une Revue Future Oncology Année : 2021

Toward a doxorubicin-loaded bioinspired bone cement for the localized treatment of osteosarcoma

Thomas Martinez
  • Fonction : Auteur
Stéphanie Sarda
Agnès Dupret-Bories
Cédric Charvillat
  • Fonction : Auteur
Fabrice Projetti

Résumé

Aims: Osteosarcoma represents the second most common cause of death in children and young adults. No biomaterial allowing local drug delivery has been specifically developed. However, a biocompatible bioactive implantable material could prevent some amputations, and the local release of an antitumor agent could limit risks of relapse and metastasis. Methods: We propose a proof of concept of a self-setting paste combining amorphous calcium phosphate and doxorubicin-loaded particles of bone-like carbonated nanocrystalline apatite, as a means of local release. Results: The cement formulation and doping, first with folic acid and then with doxorubicin, was successful. Its physicochemistry was scrutinized. Preliminary in vivo data on an invasive osteosarcoma rat model suggest a limiting effect on metastatic events in the lungs without signs of toxicity.

Domaines

Chimie
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Dates et versions

hal-03753484 , version 1 (18-08-2022)

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Citer

Thomas Martinez, Stéphanie Sarda, Agnès Dupret-Bories, Cédric Charvillat, Fabrice Projetti, et al.. Toward a doxorubicin-loaded bioinspired bone cement for the localized treatment of osteosarcoma. Future Oncology, 2021, 17 (26), pp.3511-3528. ⟨10.2217/fon-2021-0128⟩. ⟨hal-03753484⟩
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