Local injection of methotrexate ultrasound guided-transvaginal

Marie Allegrini (1) , Guillaume Legendre (2) , Yohann Dabi (3) , Thibault Thubert (4) , Marine Joste (1) , Vincent Lavoue (1) , Krystel Nyangoh Timoh (1, 5)

1 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
2 CHU Angers - Centre Hospitalier Universitaire d'Angers
3 CHU Tenon [AP-HP]
4 CHU Nantes - Centre Hospitalier Universitaire de Nantes
5 LTSI - Laboratoire Traitement du Signal et de l'Image

Non-tubal ectopic pregnancies can be located in the uterine portion of the tube (interstitial or cornual), in the cervix (cervical), in a cesarian scar, in the ovary, or intra-abdominally. Even though they are rare, they are associated with a high mortality. Invasive surgeries such as cornuectomy and hysterectomy were common to treat them in case of hemorrhage. Thanks to recent advances in imaging techniques, diagnosis of non-tubal ectopic pregnancy is made earlier and conservative management has been developed in order to respect fertility of patients. Beyond these treatments, systemic or local injection of Methotrexate shows very good success.In the article, we aimed to describe the technics of vaginal injection of in situ methotrexate with ultrasound guidance.

Mots clés: Non-tubal ectopic pregnancy; Surgery; Fertility; Methotrexate in situ injection-ultrasound; Vaginal

Domaines: Ingénierie biomédicale; Gynécologie et obstétrique

Marie Allegrini, Guillaume Legendre, Yohann Dabi, Thibault Thubert, Marine Joste, et al.. Local injection of methotrexate ultrasound guided-transvaginal. Journal of Gynecology Obstetrics and Human Reproduction, 2022, 51 (7), pp.102419. ⟨10.1016/j.jogoh.2022.102419⟩. ⟨hal-03714244⟩