Neurocognitive impacts of arbovirus infections

Marion Clé (1) , Patrick Eldin (2) , Laurence Briant (2) , Annie Lannuzel (3, 4) , Yannick Simonin (1) , Philippe van de Perre (1, 5) , André Cabié (3, 6) , Sara Salinas (1)

1 Pathogénèse et contrôle des infections chroniques (PCCI)
2 IRIM - Institut de Recherche en Infectiologie de Montpellier
3 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
4 ICM - Institut du Cerveau = Paris Brain Institute
5 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
6 MAITC EA 4537 - Maladies infectieuses et tropicales dans la Caraïbe

Arthropod-borne viruses or arbovirus, are most commonly associated with acute infections, resulting on various symptoms ranging from mild fever to more severe disorders such as hemorrhagic fever. Moreover, some arboviral infections can be associated with important neuroinflammation that can trigger neurological disorders including encephalitis, paralysis, ophthalmological impairments, or developmental defects, which in some cases, can lead to long-term defects of the central nervous system (CNS). This is well illustrated in Zika virus-associated congenital brain malformations but also in West Nile virus-induced synaptic dysfunctions that can last well beyond infection and lead to cognitive deficits. Here, we summarize clinical and mechanistic data reporting on cognitive disturbances triggered by arboviral infections, which may highlight growing public health issues spanning the five continents.

Mots clés: Arbovirus; Nervous system; Long-term sequelae; Cognition Background

Domaines: Maladies infectieuses; Neurobiologie; Sciences cognitives

Marion Clé, Patrick Eldin, Laurence Briant, Annie Lannuzel, Yannick Simonin, et al.. Neurocognitive impacts of arbovirus infections. Journal of Neuroinflammation, 2020, 17 (1), pp.233. ⟨10.1186/s12974-020-01904-3⟩. ⟨hal-02914961⟩