Synergistic Effects of Novel Naphthoquinone Derivatives Against Clinical Methicilin-Resistant Staphylococcus aureus Strain

Valentin Duvauchelle (1) , Chaimae Majdi (1) , David Bénimélis (1) , Catherine Dunyach-Rémy (2) , Patrick Meffre (1) , Zohra Benfodda (1)

1 CHROME - Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) / Université de Nîmes
2 CHU Nîmes - Hôpital Universitaire Carémeau [Nîmes]

The emergence of multidrug resistant (MDR) bacteria requires interest in the medical field and thereby an urgent need to develop efficient and specific methods in targeting unique bacterial cellular processes. Menadione (Vitamin K3) showed interesting properties as membrane integrity, two-component system and efflux pump disruptor. Novel series of 1,4-naphthoquinone based on menadione have been designed and synthesized starting from juglone and naphthazarin, following a Minisci-type reaction.

Domaines: Sciences de l'Homme et Société; Chimie; Chimie thérapeutique; Chimie organique

Valentin Duvauchelle, Chaimae Majdi, David Bénimélis, Catherine Dunyach-Rémy, Patrick Meffre, et al.. Synergistic Effects of Novel Naphthoquinone Derivatives Against Clinical Methicilin-Resistant Staphylococcus aureus Strain. REncontres en Chimie Organique Biologique 18 (RECOB18), Mar 2022, Aussois, France. . ⟨hal-03700525⟩