A Biosensor Based on Bound States in the Continuum and Fano Resonances in a Solid–Liquid–Solid Triple Layer

Ilyasse Quotane (1, 2) , Madiha Amrani (1, 2) , Cécile Ghouila-Houri (3, 4) , El Houssaine El Boudouti (1, 2) , Leonid Krutyansky (3, 5, 6) , Bogdan Piwakowski (3, 7) , Philippe Pernod (3, 4, 5) , Abdelkrim Talbi (3, 4, 5) , Bahram Djafari-Rouhani (3, 8)

1 LPMR, Department de Physique, Faculty of science, University Mohammed I
2 Université Mohammed Premier [Oujda]
3 IEMN - Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520
4 AIMAN-FILMS - IEMN - Acoustique Impulsionnelle & Magnéto-Acoustique Non linéaire - Fluides, Interfaces Liquides & Micro-Systèmes - IEMN
5 LIA LICS/LEMAC - Laboratoire International associé sur les phénomènes Critiques et Supercritiques en électronique fonctionnelle, acoustique et fluidique
6 Prokhorov General Physics Institute of the Russian Academy of Sciences
7 TPIA - IEMN - Transduction, Propagation et Imagerie Acoustique - IEMN
8 PHYSIQUE - IEMN - Physique - IEMN

We propose a simple solid–liquid–solid triple layer biosensor platform based on bound states in the continuum (BICs) and Fano resonances to detect the acoustic properties of liquids and apply the method to a mixture of water and albumin with various concentrations. The solid–liquid–solid triple layer is composed of an epoxy as a solid layer and an albumin–water mixture as a liquid layer, and the entire system is immersed in water. In this work, we show that the structure exhibits a high sensitivity (S), quality factor (Q), and figure of merit (FOM) with a better detection limit (DL) in the vicinity of the BICs where the transmission spectra exhibit Fano resonances. The Fano resonances shift towards high frequencies as the concentration increases. The detection limit can reach very small values for a small albumin concentration (4.7%). In addition, for a given concentration and layer thickness of the sensing material, we show the effect of the incidence angle on the efficiency of the sensor in terms of the sensitivity and quality factor. The proposed structure can be designed from low-cost material and can be used as a sensor to detect different types of liquids and gases as well.

Mots clés: bound states in continuum (BIC); fano resonance; phononic crystal; biosensor

Domaines: Sciences de l'ingénieur [physics]

Ilyasse Quotane, Madiha Amrani, Cécile Ghouila-Houri, El Houssaine El Boudouti, Leonid Krutyansky, et al.. A Biosensor Based on Bound States in the Continuum and Fano Resonances in a Solid–Liquid–Solid Triple Layer. Crystals, 2022, 12 (5), pp.707. ⟨10.3390/cryst12050707⟩. ⟨hal-03675361⟩