Delay between COVID-19 complete vaccination and SARS-CoV-2 infection among healthcare workers - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Vaccine Année : 2022

Delay between COVID-19 complete vaccination and SARS-CoV-2 infection among healthcare workers

Résumé

OBJECTIVES: Healthcare workers (HCWs), at increased risk of coronavirus disease 2019 (COVID-19) were among the primary targets for vaccination, which became mandatory for them on September 15th, 2021 in France. In November they were confronted to the fifth COVID-19 wave despite excellent vaccine coverage. We aimed to estimate the incidence of SARS-CoV-2 infection after complete vaccination among HCWs with different vaccination schemes, and its determinants. METHODS: We enrolled all HCWs in the university hospital of Rennes, France who had received complete vaccination (two doses of COVID-19 vaccine). The delay from last vaccination dose to SARS-CoV-2 infection was computed.Fitted mixed Cox survival model with a random effect applied to exposure risk periods to account for epidemic variation was used to estimate the determinants of SARS-CoV-2 infection after complete vaccination. RESULTS: Of the 6674 (82%) HCWs who received complete vaccination (36% BNT162b2, 29% mRNA-1273, and 34% mixed with ChAdOx1 nCoV-19) and were prospectively followed-up for a median of 7.0 [6.3-8.0] months, 160 (2.4%) tested positive for SARS-CoV-2 by RT-PCR. Incidence density of SARS-CoV-2 infection after complete vaccination was 3.39 [2.89-3.96] infections per 1000 person-month. Median time from vaccine completion to SARS-CoV-2 infection was 5.5 [3.2-6.6] months. Using fitted mixed Cox regression with the delay as a time-dependent variable and random effect applied to exposure risk periods, age (P < 0.001) was independently associated with the incidence of SARS-CoV-2 infection. Vaccine schemes were not associated with SARS-CoV-2 infection (P = 0.068). A period effect was significantly associated with the incidence of SARS-CoV-2 infection (P < 0.001). CONCLUSIONS: In this real-world study, incidence of SARS-CoV-2 infection increases with time in fully vaccinated HCWs with no differences according to the vaccination scheme. The short delay between complete vaccination and incident SARS-CoV-2 infection highlights the need for sustained barrier measures even in fully vaccinated HCWs.
Fichier principal
Vignette du fichier
Saade et al - 2022- Delay between COVID-19 complete vaccination_Manuscript_Clean_Vaccine_R.pdf (934.9 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03660247 , version 1 (30-06-2022)

Identifiants

Citer

Anastasia Saade, Leo Cha, Emilie Tadié, Bruno Jurado, Alix Le Bihan, et al.. Delay between COVID-19 complete vaccination and SARS-CoV-2 infection among healthcare workers. Vaccine, 2022, 40 (23), pp.3159-3164. ⟨10.1016/j.vaccine.2022.04.045⟩. ⟨hal-03660247⟩
84 Consultations
11 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More