Impact of molecular rigidity on the gene delivery efficiency of core–shell tecto dendrimers

Dayuan Wang (1) , Liang Chen (1) , Yue Gao (1) , Cong Song (1) , Zhijun Ouyang (1) , Changsheng Li (1) , Serge Mignani (2, 3) , Jean-Pierre Majoral (4) , Xiangyang Shi (1, 2) , Mingwu Shen (1)

1 CCEB - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University
2 Centro de Química da Madeira
3 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
4 LCC - Laboratoire de chimie de coordination

We report the construction of two types of core–shell tecto dendrimers (CSTDs) with different core rigidities to illustrate the impact of molecular rigidity on their gene delivery efficiency. Our study reveals that CSTDs designed with rigid cores enable promoted gene delivery, providing many possibilities for a wide range of gene delivery-associated biomedical applications.

Domaines: Chimie de coordination

Dayuan Wang, Liang Chen, Yue Gao, Cong Song, Zhijun Ouyang, et al.. Impact of molecular rigidity on the gene delivery efficiency of core–shell tecto dendrimers. Journal of materials chemistry‎ B, 2021, 9 (31), pp.6149-6154. ⟨10.1039/D1TB01328A⟩. ⟨hal-03658965⟩