Integrated platform for culture, observation, and parallelized electroporation of spheroids

Pauline Bregigeon (1) , Charlotte Rivière (2) , Laure Franqueville (1) , Christian Vollaire (3) , Julien Marchalot (1) , Marie Frénéa-Robin (1)

1 BioIng - Ampère, Département Bioingénierie
2 iLM - BIOPHYSIQUE - iLM - Biophysique
3 EE - Ampère, Département Energie Electrique

We present a new microsystem enabling in vitro culture of hundreds of spheroids in hydrogel support, their monitoring and parallel electroporation. We demonstrate its relevance for electro-chemotherapy assays of increased reproducibility.

Domaines: Micro et nanotechnologies/Microélectronique

Pauline Bregigeon, Charlotte Rivière, Laure Franqueville, Christian Vollaire, Julien Marchalot, et al.. Integrated platform for culture, observation, and parallelized electroporation of spheroids. Lab on a Chip, 2022, 22 (13), pp.2489-2501. ⟨10.1039/D2LC00074A⟩. ⟨hal-03795188⟩