Functionalized Dendrimer Platforms as a New Forefront Arsenal Targeting SARS-CoV-2: An Opportunity

Serge Mignani (1, 2) , Xiangyang Shi (2, 3) , Andrii Karpus (4) , Giovanni Lentini (5) , Jean-Pierre Majoral (4)

1 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
2 Centro de Química da Madeira
3 CCEB - College of Chemistry, Chemical Engineering and Biotechnology, Donghua University
4 LCC - Laboratoire de chimie de coordination
5 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro

The novel human coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has caused a pandemic. There are currently several marketed vaccines and many in clinical trials targeting SARS-CoV-2. Another strategy is to repurpose approved drugs to decrease the burden of the COVID-19 (official name for the coronavirus disease) pandemic. as the FDA (U.S. Food and Drug Administration) approved antiviral drugs and anti-inflammatory drugs to arrest the cytokine storm, inducing the production of pro-inflammatory cytokines. Another view to solve these unprecedented challenges is to analyze the diverse nanotechnological approaches which are able to improve the COVID-19 pandemic. In this original minireview, as promising candidates we analyze the opportunity to develop biocompatible dendrimers as drugs themselves or as nanocarriers against COVID-19 disease. From the standpoint of COVID-19, we suggest developing dendrimers as shields against COVID-19 infection based on their capacity to be incorporated in several environments outside the patients and as important means to stop transmission of SARS-CoV-2.

Mots clés: COVID-19 pandemic; SARS-CoV-2; Nanotechnology; Dendrimers; Repurposing strategy

Domaines: Chimie de coordination

Serge Mignani, Xiangyang Shi, Andrii Karpus, Giovanni Lentini, Jean-Pierre Majoral. Functionalized Dendrimer Platforms as a New Forefront Arsenal Targeting SARS-CoV-2: An Opportunity. Pharmaceutics, 2021, 13 (9), pp.1513. ⟨10.3390/pharmaceutics13091513⟩. ⟨hal-03657073⟩