Evolution in the metal-catalyzed asymmetric hydroformylation of 1,1′-disubstituted alkenes

Jèssica Margalef (1) , Joris Langlois (1) , Guillem Garcia (1) , Cyril Godard (1) , Montserrat Diéguez (1)

1 Departament de Química Física i Inorganica, Universitat Rovira i Virgili

Despite remarkable progress over the past decade, asymmetric hydroformylation (AHF) is still an underdeveloped field compared to other enantioselective transformations involving alkenes and thus has not encountered a place at an industrial scale yet. The research in AHF has been mainly focused on monosubstituted and 1,2-disubstituted substrates and many excellent reviews about its progress have been published. Less attention has been paid to the AHF of 1,1′-disubstituted alkenes although in the last years significant advances were made in expanding substrate scope and catalyst design. This review focuses on the progress made in the AHF of 1,1′-disubstituted alkenes, from the most studied alkenes bearing coordinating groups to the most challenging unfunctionalized ones.

Mots clés: Catalysts; Ligands; Rhodium; Platinum; Chiral aldehydes

Domaines: Chimie de coordination

Jèssica Margalef, Joris Langlois, Guillem Garcia, Cyril Godard, Montserrat Diéguez. Evolution in the metal-catalyzed asymmetric hydroformylation of 1,1′-disubstituted alkenes. Montserrat Diéguez; Oscar Pàmies. Advances in Catalysis, 69, Elsevier / Academic Press, pp.181-215, 2021, 978-0-12-824571-2. ⟨10.1016/bs.acat.2021.11.004⟩. ⟨hal-03652109⟩