The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease

Davies Adeloye (1) , Omer Elneima (2) , Luke Daines (1) , Krisnah Poinasamy , Jennifer K. Quint (3, 4) , Samantha Walker , Chris Brightling (2) , Salman Siddiqui (2) , John Hurst (5) , James D. Chalmers (6) , Paul Pfeffer (7, 8) , Petr Novotny (2) , Thomas Drake (1) , Liam Heaney (9) , Igor Rudan (1) , Aziz Sheikh (1) , Anthony de Soyza (10) , International Covid Airways Diseases Group , Mohammad Abdollahi , Dhiraj Agarwal , Riyad Al-Lehebi , Peter Barnes , Jagadeesh Bayry , Marcel Bonay , Louis Bont , Arnaud Bourdin (11, 12) , Thomas Brown , Gaetano Caramori , Amy Hai Yan Chan , David Dockrell , Simon Doe , Jamie Duckers , Anthony d'Urzo , Magnus Ekström , Cristóbal Esteban , Catherine Greene , Atul Gupta , Jennifer Ingram , Ee Ming Khoo , Fanny Wai San Ko , Gerard Koppelman , Brian Lipworth , Karin Lisspers , Michael Loebinger , Jose Luis Lopez-Campos , Matthew Maddocks , David Mannino , Miguel Martinez-Garcia , Renae Mcnamara , Marc Miravitlles , Pisirai Ndarukwa , Alison Pooler , Chin Kook Rhee , Peter Schwarz , Dominick Shaw , Michael Steiner , Andrew Tai , Charlotte Suppli Ulrik , Paul Walker , Michelle Williams

1 Edin. - University of Edinburgh
2 University of Leicester
3 NHLI - National Heart and Lung Institute [London]
4 Imperial College London
5 UCL - University College of London [London]
6 University of Dundee
7 Barts Health NHS Trust [London, UK]
8 QMUL - Queen Mary University of London
9 QUB - Queen's University [Belfast]
10 Newcastle University [Newcastle]
11 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
12 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]

Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.

Domaines: Pneumologie et système respiratoire

Davies Adeloye, Omer Elneima, Luke Daines, Krisnah Poinasamy, Jennifer K. Quint, et al.. The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease. The Lancet Respiratory Medicine, 2021, 9 (12), pp.1467-1478. ⟨10.1016/S2213-2600(21)00286-1⟩. ⟨hal-03647053⟩