Combined translocation with ZNF198-FGFR1 gene fusion and deletion of potential tumor suppressors in a myeloproliferative disorder - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cancer Genetics and Cytogenetics Année : 2007

Combined translocation with ZNF198-FGFR1 gene fusion and deletion of potential tumor suppressors in a myeloproliferative disorder

Virginie Eclache

Résumé

Tyrosine kinases activated by mutation or translocation are involved in the chronic phase of myeloproliferative disorders. Complementary or alternative events are not so well characterized. We report here a case of t(8;13) generating a ZNF198-FGFR1 fusion kinase gene on the derivative chromosome 13. ZNF198-FGFR1 mRNA, but not FGFR1-ZNF198, was detected by polymerase chain reaction amplification. By using fluorescence in situ hybridization with BAC clones, we mapped a deletion of about 2 megabases on the derivative chromosome 8, including the reciprocal FGFR1-ZNF198 fusion gene and the surrounding genes from 8p11 and 13q12. Potential tumor suppressor genes affected by the deletion by loss (IFT88, CRYL1, TACC1) or break (LATS2) may participate in the malignant process.

Domaines

Cancer

Dates et versions

hal-03634395 , version 1 (07-04-2022)

Identifiants

Citer

Anne Etienne, Véronique Gelsi-Boyer, Nadine Carbuccia, José Adélaïde, Gianluca Barba, et al.. Combined translocation with ZNF198-FGFR1 gene fusion and deletion of potential tumor suppressors in a myeloproliferative disorder. Cancer Genetics and Cytogenetics, 2007, 173 (2), pp.154-158. ⟨10.1016/j.cancergencyto.2006.10.004⟩. ⟨hal-03634395⟩
7 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More