Muscarinic toxins

Denis Servent (1) , Guillaume Blanchet (1) , Gilles Mourier (1) , Catherine Marquer (1) , Elodie Marcon (1) , Carole Fruchart-Gaillard (1)

1 SIMoS - Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO)

Muscarinic toxins isolated from the venom of Dendroaspis snakes may interact with a high affinity, large selectivity and various functional properties with muscarinic receptors. Therefore, these toxins are invaluable tools for studying the physiological role, molecular functioning and structural organization of the five subtypes of these G-Protein Coupled Receptors. We review the data on the most relevant results dealing with the isolation/identification, mode of action, structure/function and exploitation of these toxins and finally highlight the unresolved issues related to their pharmacological studies.

Mots clés: Muscarinic toxins; Muscarinic receptors; Three-finger fold toxins; GPCRs

Domaines: Sciences du Vivant [q-bio]

Denis Servent, Guillaume Blanchet, Gilles Mourier, Catherine Marquer, Elodie Marcon, et al.. Muscarinic toxins. Toxicon, 2011, 58 (6-7), pp.455-463. ⟨10.1016/j.toxicon.2011.08.004⟩. ⟨hal-03634380⟩