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Predictors of Functional Impairment in Bipolar Disorder: Results from 13 Cohorts from Seven Countries by The Global Bipolar Cohort Collaborative

K. Burdick 1 C. Millett 1 A. Yocum 2 C. Altimus 3 O. Andreassen 4 V. Aubin 5 R. Belzeaux 6, 7 M. Berk 8, 9 J. Biernacka 10 H. Blumberg 11 A. Cleare 12 C. Diaz‐byrd 2 C. Dubertret 13, 14 B. Etain 15, 16 L. Eyler 17 B. Forester 18 J. Fullerton 19 M. Frye 10 S. Gard 20 O. Godin 21, 22, 23 E. Haffen 24 F. Klaus 17 T. Lagerberg 4 M. Leboyer 21, 22, 23 A. Martinez‐aran 25 S. Mcelroy 26 P. Mitchell 19 E. Olie 27, 28 P. Olorunfemi 29 C. Passerieux 30, 31 A. Peters 29 D. Pham 3 M. Polosan 32, 33 J. Potter 1 M. Sajatovic 34 L. Samalin 35, 36 R. Schwan 37 M. Shanahan 1 B. Solé 25 R. Strawbridge 12 A. Stuart 8 I. Torres 38 T. Ueland 4, 39 E. Vieta 25 L. Williams 8, 40 A. Wrobel 8, 9 L. Yatham 38 A. Young 12 A. Nierenberg 29 M. Mcinnis 2 
4 NORMENT - Norwegian Centre for Mental Disorders Research [Oslo]
UiO - University of Oslo, Haukeland University Hospital, Oslo University Hospital [Oslo]
Abstract : Objectives: Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD. Methods: Thirteen cohorts from 7 countries included n=5,882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites. Each site performed a logistic regression analysis with empirically derived "higher versus lower function" as the dependent variable and selected clinical and demographic variables as predictors. Results: We found high rates of functional impairment, ranging from 41-75%. Lower community functioning was associated with depressive symptoms in 10 of 12 of the cohorts that included this variable in the analysis. Lower levels of education, a greater number of prior mood episodes, presence of a comorbid substance use disorder, and a greater total number of psychotropic medications were also associated with low functioning. Conclusions: The bipolar clinical research community is poised to work together to characterize the multi-dimensional contributors to impairment and address the barriers that impede patients' complete recovery. We must also identify the core features which enable many to thrive and live successfully with BD. A large-scale, worldwide, prospective longitudinal study focused squarely on BD and its heterogeneous presentations will serve as a platform for discovery and promote major advances toward optimizing outcomes for every individual with this illness.
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Contributor : Nathalie C. Guerineau Connect in order to contact the contributor
Submitted on : Monday, May 30, 2022 - 3:41:11 PM
Last modification on : Friday, September 9, 2022 - 10:20:08 AM
Long-term archiving on: : Wednesday, August 31, 2022 - 6:59:27 PM


Bipolar Disorders - 2022 - Bur...
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K. Burdick, C. Millett, A. Yocum, C. Altimus, O. Andreassen, et al.. Predictors of Functional Impairment in Bipolar Disorder: Results from 13 Cohorts from Seven Countries by The Global Bipolar Cohort Collaborative. Bipolar Disorders, Wiley, 2022, ⟨10.1111/bdi.13208⟩. ⟨hal-03625156⟩



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