Réparation de l’ADN et longévité : les rongeurs et nous

Bertrand Jordan (1)

1 ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé

Large differences in maximum longevity exist between different rodent species. Determination of the spontaneous and mutagen-induced mutation rates in these species by single (somatic) cell sequencing suggests more efficient DNA repair in long-lived species (including humans), but the data is too noisy to prove a strong correlation between longevity and preservation of DNA integrity.

Domaines: Sciences du Vivant [q-bio]

Bertrand Jordan. Réparation de l’ADN et longévité : les rongeurs et nous : Chroniques génomiques. Médecine/Sciences, 2022, 38 (3), pp.317-319. ⟨10.1051/medsci/2022019⟩. ⟨hal-03620427⟩