Hydrogel based lipid-oligonucleotides: a new route to self-delivery of therapeutic sequences

Sébastien Benizri , Alexandra Gaubert (1) , Charlotte Soulard , Étienne Gontier (1) , Isabelle Svahn , Palma Rocchi , Gaëlle Vacher (1) , Philippe Barthélémy (1)

1 ARNA - Acides Nucléiques : Régulations Naturelle et Artificielle

Lipid-oligonucleotide conjugates self-assemble to form entangled pearl-necklace networks stabilizing gels. Owing to these properties, the oligonucleotide sequences exhibit a prolonged release after subcutaneous administration.

Domaines: Chimie; Sciences du Vivant [q-bio]

Sébastien Benizri, Alexandra Gaubert, Charlotte Soulard, Étienne Gontier, Isabelle Svahn, et al.. Hydrogel based lipid-oligonucleotides: a new route to self-delivery of therapeutic sequences. Biomaterials Science, 2021, 9 (10), pp.3638-3644. ⟨10.1039/d1bm00273b⟩. ⟨hal-03599173⟩