Poly-L-Lysine and Human Plasmatic Fibronectin Films as Proactive Coatings to Improve Implant Biointegration - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Bioengineering and Biotechnology Année : 2022

Poly-L-Lysine and Human Plasmatic Fibronectin Films as Proactive Coatings to Improve Implant Biointegration

Anamar Miranda
  • Fonction : Auteur
Carla Palomino-Durand
Houda Morakchi-Goudjil
  • Fonction : Auteur
Mathilde Massonie
  • Fonction : Auteur
Rémy Agniel
  • Fonction : Auteur
Hassan Rammal
Emmanuel Pauthe
  • Fonction : Auteur
Adeline Gand
  • Fonction : Auteur
  • PersonId : 780794
  • IdRef : 131331647

Résumé

The success of stable and long-term implant integration implies the promotion, control, and respect of the cell microenvironment at the site of implantation. The key is to enhance the implant–host tissue cross talk by developing interfacial strategies that guarantee an optimal and stable seal of soft tissue onto the implant, while preventing potential early and late infection. Indeed, implant rejection is often jeopardized by lack of stable tissue surrounding the biomaterial combined with infections which reduce the lifespan and increase the failure rate of implants and morbidity and account for high medical costs. Thin films formed by the layer-by-layer (LbL) assembly of oppositely charged polyelectrolytes are particularly versatile and attractive for applications involving cell–material contact. With the combination of the extracellular matrix protein fibronectin (Fn, purified from human plasma) and poly-L-lysine (PLL, exhibiting specific chain lengths), we proposed proactive and biomimetic coatings able to guarantee enhanced cell attachment and exhibiting antimicrobial properties. Fn, able to create a biomimetic interface that could enhance cell attachment and promote extracellular cell matrix remodeling, is incorporated as the anionic polymer during film construction by the LbL technic whereas PLL is used as the cationic polymer for its capacity to confer remarkable antibacterial properties.

Dates et versions

hal-03593762 , version 1 (02-03-2022)

Identifiants

Citer

Anamar Miranda, Damien Seyer, Carla Palomino-Durand, Houda Morakchi-Goudjil, Mathilde Massonie, et al.. Poly-L-Lysine and Human Plasmatic Fibronectin Films as Proactive Coatings to Improve Implant Biointegration. Frontiers in Bioengineering and Biotechnology, 2022, 9, ⟨10.3389/fbioe.2021.807697⟩. ⟨hal-03593762⟩
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