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Modeling pre-drug toxicity in liver cell cultures and organoids

B. Clement 1, * 
Abstract : Drug administration is not without risk, particularly in the context of an under-lying chronic disease, specific genetic and epigenetic background, drug mis(over)use or non-compliance with medical prescriptions. The liver, a central organ of xenobiotic metabo-lism, is a main target of drug toxicity. This may result in drug-induced liver injuries that can lead to death due to an acute liver failure. Predicting liver toxicity of drugs relies primarily on preclinical studies performed in animal models. Alternative models are therefore actively sought, including cellular systems capable of recapitulating the metabolic pathways of drug biotransformation and toxicity. (c) 2021 l'Academie nationale de medecine. Published by Elsevier Masson SAS. All rights reserved.
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https://hal.archives-ouvertes.fr/hal-03592804
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Submitted on : Tuesday, March 1, 2022 - 3:31:59 PM
Last modification on : Thursday, March 3, 2022 - 3:11:22 AM

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B. Clement. Modeling pre-drug toxicity in liver cell cultures and organoids. Bulletin de l'Académie Nationale de Médecine, Elsevier Masson, 2022, 206 (2), pp.219-224. ⟨10.1016/j.banm.2021.11.022⟩. ⟨hal-03592804⟩

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