Colonization versus encapsulation in cell-laden materials design: porosity and process biocompatibility determine cellularization pathways - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences Année : 2021

Colonization versus encapsulation in cell-laden materials design: porosity and process biocompatibility determine cellularization pathways

Francisco M Fernandes

Résumé

Seeding materials with living cells has been—and still is—one of the most promising approaches to reproduce the complexity and the functionality of living matter. The strategies to associate living cells with materials are limited to cell encapsulation and colonization, however, the requirements for these two approaches have been seldom discussed systematically. Here we propose a simple two-dimensional map based on materials' pore size and the cytocompatibility of their fabrication process to draw, for the first time, a guide to building cellularized materials. We believe this approach may serve as a straightforward guideline to design new, more relevant materials, able to seize the complexity and the function of biological materials. This article is part of the theme issue ‘Bio-derived and bioinspired sustainable advanced materials for emerging technologies (part 1)’.

Domaines

Matériaux

Dates et versions

hal-03592455 , version 1 (01-03-2022)

Identifiants

Citer

Cleo Parisi, Kankan Qin, Francisco M Fernandes. Colonization versus encapsulation in cell-laden materials design: porosity and process biocompatibility determine cellularization pathways. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2021, 379 (2206), ⟨10.1098/rsta.2020.0344⟩. ⟨hal-03592455⟩
23 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More