Development of the gonadotropin‐releasing hormone system

Anne Duittoz (1) , Paolo E. Forni (2) , Paolo Giacobini (3) , Matan Golan (4) , Patrice Mollard (5) , Ariel L. Negrón (6) , Sally Radovick (6) , Susan Wray (7)

1 PRC - Physiologie de la reproduction et des comportements [Nouzilly]
2 University at Albany [SUNY]
3 LilNCog - Lille Neurosciences & Cognition - U 1172
4 Agricultural Research Organization - the Volcani Center
5 IGF - Institut de Génomique Fonctionnelle
6 RWJMS - Robert Wood Johnson Medical School [Piscataway, NJ]
7 NINDS - National Institute of Neurological Disorders and Stroke [Bethesda]

This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.

Mots clés: GnRH; Development; Guidance cues; Migratory pathway; Olfactory ensheathing cells; Olfactory placode; Synaptic and paracrine signals; Terminal nerve; Transcription factors

Domaines: Embryologie et organogenèse; Médecine vétérinaire et santé animale; Génomique, Transcriptomique et Protéomique [q-bio.GN]; Neurobiologie

Anne Duittoz, Paolo E. Forni, Paolo Giacobini, Matan Golan, Patrice Mollard, et al.. Development of the gonadotropin‐releasing hormone system. Journal of Neuroendocrinology, 2022, 34 (5), pp.e13087. ⟨10.1111/jne.13087⟩. ⟨hal-03590756⟩