Non-proteolytic ubiquitylation in cellular signaling and human disease

Yongrong Liao (1) , Izabela Sumara (1) , Evanthia Pangou (1)

1 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire

Abstract Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation. However it can also result in non-proteolytic events which play important functions in cellular processes such as intracellular signaling, membrane trafficking, DNA repair and cell cycle. Emerging evidence demonstrates that dysfunction of non-proteolytic ubiquitylation is associated with the development of multiple human diseases. In this review, we summarize the current knowledge and the latest concepts on how non-proteolytic ubiquitylation pathways are involved in cellular signaling and in disease-mediating processes. Our review, may advance our understanding of the non-degradative ubiquitylation process.

Domaines: Sciences du Vivant [q-bio]

Yongrong Liao, Izabela Sumara, Evanthia Pangou. Non-proteolytic ubiquitylation in cellular signaling and human disease. Communications Biology, 2022, 5 (1), pp.114. ⟨10.1038/s42003-022-03060-1⟩. ⟨hal-03564096⟩