Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor

Frédéric Coin (1) , Jean-Marc Egly (1)

1 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire

In this issue of Molecular Cell, Nilson et al. (2015) took advantage of THZ1, a recently described covalent inhibitor of the TFIIH kinase CDK7, to further characterize the role of this enzyme in the early stages of transcription and postprocessing events. They unveiled an unexpected function of CDK7 in RNA polymerase II pausing and mRNA capping.

Domaines: Sciences du Vivant [q-bio]

Frédéric Coin, Jean-Marc Egly. Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor. Molecular Cell, 2015, 59 (4), pp.513-514. ⟨10.1016/j.molcel.2015.08.006⟩. ⟨hal-03542266⟩