Activation of P-TEFb by RBM7: To Live or Let Die

Nicolas Le May (1) , Frédéric Coin (1)

1 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire

In this issue of Molecular Cell, Bugai et al. (2019) unveil that a key step of the pro-survival cellular response to a genotoxic attack is the activation of P-TEFb by RBM7. This crucial step triggers RNA polymerase II release from promoter-proximal pausing and expression of DNA damage response genes.

Domaines: Sciences du Vivant [q-bio]

Nicolas Le May, Frédéric Coin. Activation of P-TEFb by RBM7: To Live or Let Die. Molecular Cell, 2019, 74 (2), pp.223-224. ⟨10.1016/j.molcel.2019.03.039⟩. ⟨hal-03542242⟩