Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

Martin Marek (1) , Elizabeth Ramos-Morales (1) , Gisele F A Picchi-Constante , Theresa Bayer , Carina Norström , Daniel Herp (2) , Policarpo A Sales-Junior , Eloise P Guerra-Slompo , Kristin Hausmann , Alokta Chakrabarti (2) , Tajith B Shaik , Annika Merz , Edouard Troesch , Karin Schmidtkunz , Samuel Goldenberg , Raymond J Pierce , Marina M Mourão , Manfred Jung , Johan Schultz , Wolfgang Sippl , Nilson I T Zanchin , Christophe Romier

1 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
2 Albert-Ludwigs-Universität Freiburg

Highlights d Trypanosome histone deacetylases (HDACs) significantly diverge from human HDACs d T. cruzi class I HDACs tcDAC1 and tcDAC2 are essential to the parasite viability d tcDAC2 deacetylase activity can be inhibited by targeting its atypical active site d T. cruzi parasites can be targeted through a tcDAC2-specific inhibitor

Domaines: Sciences du Vivant [q-bio]

Martin Marek, Elizabeth Ramos-Morales, Gisele F A Picchi-Constante, Theresa Bayer, Carina Norström, et al.. Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. Cell Reports, 2021, 37, ⟨10.1016/j.celrep.2021.110129⟩. ⟨hal-03504175⟩