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Adherence profiles in kidney transplant patients: Causes and consequences

Claire Villeneuve 1, 2, * Annick Rousseau 2, 3, 4 Jean-Phillipe Rerolle 2, 3 Lionel Couzi 5 Nassim Kamar 6, 7, 8 Marie Essig 2, 3 Isabelle Etienne 9 Pierre-Francois Westeel 10 Matthias Buchler 3, 11 Laure Esposito 6 Antoine Thierry 3, 12 Pierre Marquet 1, 2, 3 Caroline Monchaud 1, 2, 3 
* Corresponding author
3 FHU SUPORT - Fédération Hospitalo-universitaire SUrvival oPtimization in ORgan Transplantation
IRTOMIT - Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques, RESINFIT - Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques, Cellules Dendritiques, Immunomodulation et Greffes, CHU Poitiers - Centre hospitalier universitaire de Poitiers , CHU Limoges, IPPRITT - Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation
Abstract : Objective: Adherence is a dynamic phenomenon and a critical determinant of transplant patients outcome. The objective of this longitudinal study was to explore adherence in kidney transplant patients followed-up for up to three years after transplantation. Methods: Adherence was repeatedly estimated using the Morisky-Green-Levine 4-Item Medication Adherence Scale, in two successive cohorts of 345 (EPIGREN) and 367 (EPHEGREN) kidney transplant recipients. Mixed effect modeling with latent processes and latent classes was used to describe adherence time-profiles. Results: Two latent classes were identified. The adherent class represented 85% of the patients. Patients of the poorer-adherence class displayed a lower adherence at one month (p<10-3), which worsened over time. Good adherence was associated with age >50 years, fewer depression episodes (5% vs. 13%, p = 0.001) and a better mental health component of quality of life (MCS-SF36 47 ± 11 vs. 41 ± 13, p = 0.015). Survival without acute rejection episodes was longer in the adherent class (p = 0.004). Conclusions: The risk of poor adherence in renal transplant patients can be detected as early as one month post-transplantation, using appropriate and easy tools adapted to routine monitoring. Practice implications: An early focus on vulnerable patients should allow putting into place actions in order to reduce the risk of poor outcome related to poor adherence.
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Submitted on : Thursday, July 21, 2022 - 7:43:37 AM
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Claire Villeneuve, Annick Rousseau, Jean-Phillipe Rerolle, Lionel Couzi, Nassim Kamar, et al.. Adherence profiles in kidney transplant patients: Causes and consequences. Patient Education and Counseling, Elsevier, 2020, 103 (1), pp.189 - 198. ⟨10.1016/j.pec.2019.08.002⟩. ⟨hal-03488791⟩

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