New microfluidic designs for high-throughput analysis of angiogenesis, blood vessel permeability and endothelial activation
Résumé
Angiogenesis is the process by which new blood vessels arise from existing ones. Angiogenesis is involved in human cancers; new blood vessels favor tumor development by bringing oxygen and nutrients to the developing mass. We designed angiogenesis-on-chip devices using a viscosity finger patterning technique for creating established blood vessels in hydrogels on which endothelial integrity and permeability could be assessed, and from which sprouting angiogenesis may be induced. These BioMEMS are designed in multiwell plate format to be used for high throughput drug screening.