Impact of Carbon Fluoroxide Nanoparticles on Cell Proliferation

Alain Géloën (1) , Gauhar Mussabek (2) , Alexander Kharin (1, 3) , Tetiana Serdiuk (1, 4) , Sergei A Alekseev (5) , Vladimir Lysenko (6)

1 LEM - Laboratoire d'Ecologie Microbienne - UMR 5557
2 KazNU - Al-Farabi Kazakh National University [Almaty]
3 The National Research Nuclear University MEPhI (Moscow Engineering Physics Institute) [Moscow, Russia]
4 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
5 Taras Shevchenko National University of Kyiv
6 iLM - FENNEC - iLM - Formation, élaboration de nanomatériaux et cristaux

Cytotoxicity of fluorescent carbon fluoroxide (CFO) nanoparticles (NPs) was studied in a label-free manner on several cancer and non-cancer cell lines. A direct cytotoxic effect of the CFO NPs was clearly observed by a suppression of cell proliferation. The real-time measurement of cell activities allowed to quantify the impact of the uptaken NPs on cell proliferation and after washout of the NPs from the cell culture medium. The results show more toxic effects of the CFO NPs on cancer than on non-cancer cell lines. The notion of NPs biocompatibility must be related to a maximum concentration value of the NPs acceptable for a given cell type. Furthermore, the cytotoxicity effects of NPs should be studied not only during their direct exposure to cells but also after their washout from the culture medium

Mots clés: cancer cell; xCELLigence; nanoparticles; cellular uptake; cytotoxicity

Domaines: Toxicologie; Matériaux; Interactions cellulaires [q-bio.CB]

Alain Géloën, Gauhar Mussabek, Alexander Kharin, Tetiana Serdiuk, Sergei A Alekseev, et al.. Impact of Carbon Fluoroxide Nanoparticles on Cell Proliferation. Nanomaterials, 2021, 11 (12), pp.3168. ⟨10.3390/nano11123168⟩. ⟨hal-03444199⟩