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Within-host genetic micro-diversity of Mycobacterium tuberculosis and the link with tuberculosis disease features

Abstract : Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) complex, is still the number one deadly contagious disease. Mtb infection results in a wide spectrum of clinical presentations and severity symptoms, but without proven Mtb genetic determinants. Thanks to a collection of 355 clinical isolates with associated patient’s clinical data, we showed that Mtb micro-diversity within patient isolates is strongly correlated with TB-associated severity scores. Interestingly, this diversity is driven by a selection pressure to adapt to different lifestyles related to the infection site. Taken together, these results provide a new insight to better understand TB pathophysiology. Furthermore, Mtb micro-diversity could be envisioned as a new prognostic tool to improve the management of TB patients.
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Preprints, Working Papers, ...
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https://hal.archives-ouvertes.fr/hal-03433572
Contributor : Laurent Jacob Connect in order to contact the contributor
Submitted on : Wednesday, November 17, 2021 - 6:49:36 PM
Last modification on : Saturday, August 6, 2022 - 3:51:46 AM

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Charlotte Genestet, Elisabeth Hodille, François Massol, Guislaine Refrégier, Alexia Barbry, et al.. Within-host genetic micro-diversity of Mycobacterium tuberculosis and the link with tuberculosis disease features. 2021. ⟨hal-03433572⟩

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