CHARACTERIZATION OF SPATIAL REPELLENT, CONTACT IRRITANT, AND TOXICANT CHEMICAL ACTIONS OF STANDARD VECTOR CONTROL COMPOUNDS - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of the American Mosquito Control Association Année : 2009

CHARACTERIZATION OF SPATIAL REPELLENT, CONTACT IRRITANT, AND TOXICANT CHEMICAL ACTIONS OF STANDARD VECTOR CONTROL COMPOUNDS

Résumé

A previously described modular high-throughput screening system was used to characterize the spatial repellent, contact irritant, and toxicant chemical actions of 14 compounds historically used or under investigation for vector control. The response of F 1-F 4 Aedes aegypti (Thailand strain) to various concentrations of 4 organochlorines (chlordane, DDT, dieldrin, methoxychlor); 4 pyrethroids (alphacypermethrin, cypermethrin, deltamethrin, permethrin); 3 organophosphates (chlorpyrophos methyl, fenitrothion, malathion); 2 carbamates (bendiocarb, propoxur); and 1 pyrazole (chlorfenapyr) were evaluated. Results show chemicals exert different combinations of contact irritant, spatial repellent, and toxic actions. This is true even within the same chemical class. These actions can be ordered for each chemical based on the testing dose at which the specific response is elicited. Data also indicate that behavioral responses to spatial repellent and contact irritant actions are separate (or independent) from the toxic action of a compound. Results from pyrethroid and DDT assays also show chemicals can induce behaviormodifying actions, such as contact irritancy and spatial repellency, which will reduce man-vector contact, despite evidence of insecticide resistance within the test population. These findings support previous laboratory and field studies showing man-vector contact and disease transmission are routinely interrupted by spatial repellent and contact irritant actions of common public health insecticides. Studies similar to that presented here can be used as baseline evidence for expected vector responses and support best approaches for more detailed behavioral research.
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Dates et versions

hal-03433455 , version 1 (17-11-2021)

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Nicole L Achee, Michael R Sardelis, Isabelle Dusfour, Kamlesh R Chauhan, John P Grieco. CHARACTERIZATION OF SPATIAL REPELLENT, CONTACT IRRITANT, AND TOXICANT CHEMICAL ACTIONS OF STANDARD VECTOR CONTROL COMPOUNDS. Journal of the American Mosquito Control Association, 2009, 25 (2), pp.156-167. ⟨10.2987/08-5831.1⟩. ⟨hal-03433455⟩
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