Th17-Immune Response in Patients With Membranous Nephropathy Is Associated With Thrombosis and Relapses

Marion Cremoni (1, 2) , Vesna Brglez (2, 3) , Sandra Perez (4) , Fabrice Decoupigny (4) , Kévin Zorzi (2, 3) , Marine Andreani (1) , Alexandre Gérard (1) , Sonia Boyer-Suavet (2) , Caroline Ruetsch (5) , Sylvia Benzaken (5) , Vincent Esnault (1) , Barbara Seitz-Polski (1)

1 Service de Néphrologie-Dialyse-Transplantation, CHU de Nice, Université Côte d'Azur, France
2 URRIS UR2CA - Unité de Recherche Clinique de la Côte d’Azur
3 Centre de Référence Maladies Rares Syndrome Néphrotique Idiopathique, CHU de Nice
4 ESPACE - Étude des Structures, des Processus d’Adaptation et des Changements de l’Espace
5 Laboratoire d’Immunologie [CHU Nice]

Exciting times for the field of renal autoimmune diseases have begun. In 2021, for the first time, two new drugs belimumab (1) and voclosporin ( 2) are approved for the treatment of lupus nephritis (LN) (1, 2). Other novel targeted therapies demonstrate clinical efficacy in large, randomized trials, such as avacopan for ANCA-associated vasculitis (AAV) (3), imlifidase for Goodpasture’s disease and iptacopan for IgA nephropathy (IgAN). Pathogenic molecules are specifically targeted by new drugs that help to uncover novel aspects of disease mechanisms leading to glomerulonephritis. Simultaneously, the field is boosted by novel big data technologies on the single cell levels such as high-sensitive multi-color flow cytometry, single-cell genomics (single-cell RNA sequencing - scRNAseq), single cell metabolomics and proteomics. The novel treatment options in renal autoimmune diseases almost simultaneously require new immunomonitoring tools. ‘Immunomonitoring’includes the wide range of approaches to monitoring immune responses by the cellular immune system (e.g. T-cells, B-cells, plasma cells, dendritic cells, neutrophils etc.), or by the humoral immune system (e.g. cytokines, (auto-)antibodies, urinary markers, etc.). Monitoring relevant immune responses in patients with renal autoimmune diseases helps us to better understand a) the underpinning immunological pathophysiology of these diseases; b) the beneficial effects of novel treatments on autoimmunity; and c) can potentially help doctors and patients guide a personalized treatment strategy, adding information on immunological (non-)response to a clinical (non-) response treatment and on disease prognosis. In the present Research Topic, we have been able to collect for you a vast amount of research addressing novel ways and the role of immunomonitoring in the broad range of renal autoimmune disease including LN, AAV, IgAN, idiopathic membranous nephropathy (iMN) and complement-mediated disease (CMD).

Domaines: Médecine humaine et pathologie

Marion Cremoni, Vesna Brglez, Sandra Perez, Fabrice Decoupigny, Kévin Zorzi, et al.. Th17-Immune Response in Patients With Membranous Nephropathy Is Associated With Thrombosis and Relapses: Th17-Immune Response in Patients With Membranous Nephropathy Is Associated With Thrombosis and Relapses. Frontiers in Immunology. Monitoring Immune Responses in Renal Autoimmune and Autoinflammatory Diseases, 2021, ISBN 978-2-88971-381-3. ⟨10.3389/978-2-88971-381-3⟩. ⟨hal-03427278⟩