Cyclosporin A Prevents the Hypoxic Adaptation by Activating Hypoxia-inducible Factor-1α Pro-564 Hydroxylation

Gisela D’angelo (1) , Eric Duplan (2) , Paul Vigne (2) , Christian Frelin (2)

1 Biologie Cellulaire et Cancer
2 IPMC - Institut de pharmacologie moléculaire et cellulaire

This is an Open Access article under the CC BY license.

Mots clés: GST; glutathione S-transferase; HRE; hypoxia-responsive elements; ODD; oxygen-dependent degradation; PHD; prolyl hydroxylase; vHL; von Hippel-Lindau; Luc; luciferase; PBS; phosphate-buffered saline

Domaines: Sciences du Vivant [q-bio]

Gisela D’angelo, Eric Duplan, Paul Vigne, Christian Frelin. Cyclosporin A Prevents the Hypoxic Adaptation by Activating Hypoxia-inducible Factor-1α Pro-564 Hydroxylation. Journal of Biological Chemistry, 2003, 278, pp.15406 - 15411. ⟨10.1074/jbc.m211293200⟩. ⟨hal-03424484⟩