Design, Synthesis, Evaluation and Structure of Allenic 1α,25‐Dihydroxyvitamin D 3 Analogs with Locked Mobility at C‐17 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemistry - A European Journal Année : 2021

Design, Synthesis, Evaluation and Structure of Allenic 1α,25‐Dihydroxyvitamin D 3 Analogs with Locked Mobility at C‐17

Résumé

Vitamin D receptor ligands have potential for the treatment of hyperproliferative diseases and disorders related to the immune system. However, hypercalcemic effects limit their therapeutical uses and call for the development of tissue-selective new analogs. We have designed and synthesized the first examples of 1α,25-dihydroxyvitamin D3 analogs bearing an allenic unit attached to the D ring to restrict the side-chain conformational mobility. The triene system was constructed by a Pd0 -mediated cyclization/Suzuki-Miyaura cross-coupling process in the presence of an allenic side chain. The allenic moiety was built through an orthoester-Claisen rearrangement of a propargylic alcohol. The biological activity and structure of (22S)-1α,25-dihydroxy-17,20-dien-24-homo-21-nor-vitamin D3 bound to binding domain of the vitamin D receptor, provide information concerning side-chain conformational requirements for biological activity.
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Dates et versions

hal-03424048 , version 1 (16-11-2021)

Identifiants

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Ramón Fraga, Kateryna Len, Regis Lutzing, Gilles Laverny, Julian Loureiro, et al.. Design, Synthesis, Evaluation and Structure of Allenic 1α,25‐Dihydroxyvitamin D 3 Analogs with Locked Mobility at C‐17. Chemistry - A European Journal, 2021, 27 (53), pp.13384-13389. ⟨10.1002/chem.202101578⟩. ⟨hal-03424048⟩
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