Aromatic Trifluoromethylselenolation via Pd-catalyzed C-H functionalization

Kevin Grollier (1) , Emmanuel Chefdeville , Erwann Jeanneau (2) , Thierry Billard (1)

1 ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
2 Centre de diffractométrie Henri Longchambon

The synthesis of trifluoromethylselenolated aromatic molecules is described via an auxiliary-assisted, palladium catalyzed, C-H bonds functionalization with trifluoromethyl tolueneselenosulfonate as reagent. The mono-or bis-products can be preferentially formed. Some mechanistic investigations were realized to better understand the reaction. This methodology was also extended to fluoroalkylselenyl groups.

Domaines: Chimie organique

Kevin Grollier, Emmanuel Chefdeville, Erwann Jeanneau, Thierry Billard. Aromatic Trifluoromethylselenolation via Pd-catalyzed C-H functionalization. Chemistry - A European Journal, 2021, 27 (50), pp.12910-12916. ⟨10.1002/chem.202102121⟩. ⟨hal-03407550⟩