Multiphase chemical engineering as a tool in modelling electromediated reactions-Example of Rh complex-mediated regeneration of NADH

Wassim El Housseini (1, 2) , Mathieu Etienne (1) , Alain Walcarius (1) , Francois Lapicque (2)

1 LCPME - Laboratoire de Chimie Physique et Microbiologie pour les Matériaux et l'Environnement
2 LRGP - Laboratoire Réactions et Génie des Procédés

On the basis of the electromediated regeneration of beta-nicotinamide adenine dinucleotide hydrate (NADH) by chloro(2,2′-bipyridyl) (pentamethylcyclopentadienyl)-rhodium (III) chloride complex – Rh(III), the manuscript describes a modelling approach inspired by multiphase chemical engineering with gas absorption with chemical reaction. Here, the electrode surface is assimilated to the gas–liquid interface, and the reducing Rh(I) formed at the electrode corresponds to the dissolved gas. This method allows the kinetics of the liquid phase reaction between NAD+ and Rh(I) to be estimated and the beneficial effect of NAD+ concentration on the reduction current of Rh(III) to be successfully predicted. Moreover, because of the fast kinetics of the liquid phase reaction, the overall mediated regeneration of NADH by the redox Rh couple can be viewed as occurring as the direct reduction of NAD+ to NADH. The approach could be applied to other electromediated processes, upon sufficient knowledge of the system physico-chemical specificities.

Mots clés: gas-liquid absorption; reaction kinetics; Beta-nicotinamide adenine dinucleotide hydrate; chloro(2; 2′-bipyridyl) (pentamethylcyclopentadienyl)-rhodium (III); electromediated reactions

Domaines: Autre; Génie chimique; Biochimie [q-bio.BM]

Wassim El Housseini, Mathieu Etienne, Alain Walcarius, Francois Lapicque. Multiphase chemical engineering as a tool in modelling electromediated reactions-Example of Rh complex-mediated regeneration of NADH. Chemical Engineering Science, 2022, 247, pp.117055. ⟨10.1016/j.ces.2021.117055⟩. ⟨hal-03407265⟩