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Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells
Gautier Follain
1
Nael Osmani
1
Sofia Azevedo
1
Guillaume Allio
1
Luc Mercier
1
Matthia Karreman
2
Gergely Solecki
3
Maria Garcia-Leon
1
Olivier Lefebvre
1
Nina Fekonja
1
Claudia Hille
4
Vincent Chabannes
5
Guillaume Dollé
5
Thibaut Métivet
5
Francois Der Hovsepian
5
Christophe Prud'Homme
5
Angélique Pichot
1
Nicodème Paul
1
Raphaël Carapito
1
Siamak Bahram
1
Bernhard Ruthensteiner
6
André Kemmling
7
Susanne Siemonsen
4
Tanja Schneider
4
Jens Fiehler
4
Markus Glatzel
4
Frank Winkler
3
Yannick Schwab
2
Klaus Pantel
4
Sebastien Harlepp
1, 8
Jacky G Goetz
1
Luc Mercier 1
Author
Matthia Karreman 2
Author
Gergely Solecki 3
Author
Maria Jesus Garcia-Leon 1
Author
Olivier Lefebvre 1
Author
Nina Fekonja 1
Author
Claudia Hille 4
Author
Vincent Chabannes 5
Author IdHAL : vincent-chabannes
Guillaume Dollé 5
Author Employer institution : Université de Strasbourg IdHAL : gdolle ResearcherId : http://www.researcherid.com/rid/O-1667-2014 ORCID : https://orcid.org/0000-0002-5844-2536
Thibaut Métivet 5
Author IdHAL : thibaut-metivet
Francois Der Hovsepian 5
Author Employer institution : Université de Strasbourg
Christophe Prud'Homme 5
Author IdHAL : christophe-prudhomme ORCID : https://orcid.org/0000-0003-2287-2961
Bernhard Ruthensteiner 6
Author
André Kemmling 7
Author
Susanne Siemonsen 4
Author
Tanja Schneider 4
Author
Klaus Pantel 4
Author
Sebastien Harlepp 1, 8
Author Employer institution : Université de Strasbourg
Jacky G Goetz 1
Author
1
Immuno-Rhumatologie Moléculaire (1 Place de l'Hôpital 67000 Strasbourg - France)
- UNISTRA - Université de Strasbourg : UMRS1109 (4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1109 (101, rue de Tolbiac, 75013 Paris - France)
2
EMBL - European Molecular Biology Laboratory [Heidelberg] (Meyerhofstraße 1, 69117 Heidelberg, Germany - Germany)
3
Heidelberg University Hospital [Heidelberg] (Im Neuenheimer Feld 400
69120 Heidelberg - Germany)
4
UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (Martinistraße 52
20251 Hamburg - Germany)
5
IRMA - Institut de Recherche Mathématique Avancée (7 rue René-Descartes, 67084 Strasbourg Cedex, France - France)
- UNISTRA - Université de Strasbourg (4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7501 (France)
6
Zoologische Staatssammlung München (Germany)
7
UKSH - University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein (Germany)
- Kiel University (Christian-Albrechts-Platz 4 24118 Kie - Germany)
8
IPCMS - Institut de Physique et Chimie des Matériaux de Strasbourg (23 rue du Loess - BP 43 - 67034 Strasbourg Cedex 2 - France - France)
- UNISTRA - Université de Strasbourg (4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7504 (France)
- FMNGE - Matériaux et nanosciences d'Alsace (France)
- INC - Institut de Chimie du CNRS (3 Rue Michel-Ange 75 016 Paris - France)
- UNISTRA - Université de Strasbourg : FR3627 (4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex - France)
- Université de Haute-Alsace (UHA) - Université de Haute-Alsace (UHA) Mulhouse - Colmar (2, rue des Frères Lumière F-68093 Mulhouse Cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : FR3627 (France)
- Réseau nanophotonique et optique (France)
- CNRS - Centre National de la Recherche Scientifique (France)
- UNISTRA - Université de Strasbourg : FR3678 (4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex - France)
- Université de Haute-Alsace (UHA) - Université de Haute-Alsace (UHA) Mulhouse - Colmar (2, rue des Frères Lumière F-68093 Mulhouse Cedex - France)
Abstract : Metastatic seeding is driven by cell-intrinsic and environmental cues, yet the contribution of biomechanics is poorly known. We aim to elucidate the impact of blood flow on the arrest and the extravasation of circulating tumor cells (CTCs) in vivo. Using the zebrafish embryo, we show that arrest of CTCs occurs in vessels with favorable flow profiles where flow forces control the adhesion efficacy of CTCs to the endothelium. We biophysically identified the threshold values of flow and adhesion forces allowing successful arrest of CTCs. In addition, flow forces fine-tune tumor cell extravasation by impairing the remodeling properties of the endothelium. Importantly, we also observe endothelial remodeling at arrest sites of CTCs in mouse brain capillaries. Finally, we observed that human supratentorial brain metastases preferably develop in areas with low perfusion. These results demonstrate that hemodynamic profiles at metastatic sites regulate key steps of extravasation preceding metastatic outgrowth.
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Journal articles
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https://hal.archives-ouvertes.fr/hal-01694694
Contributor : Christophe Prud'Homme Connect in order to contact the contributor
Submitted on : Tuesday, February 6, 2018 - 5:51:34 AM
Last modification on : Tuesday, April 26, 2022 - 3:38:37 AM
Long-term archiving on: : Wednesday, May 2, 2018 - 2:38:37 PM
Contributor : Christophe Prud'Homme Connect in order to contact the contributor
Submitted on : Tuesday, February 6, 2018 - 5:51:34 AM
Last modification on : Tuesday, April 26, 2022 - 3:38:37 AM
Long-term archiving on: : Wednesday, May 2, 2018 - 2:38:37 PM
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Identifiers
- HAL Id : hal-01694694, version 1
- BIORXIV : 183046
- DOI : 10.1016/j.devcel.2018.02.015
Citation
Gautier Follain, Nael Osmani, Sofia Azevedo, Guillaume Allio, Luc Mercier, et al.. Hemodynamic forces tune the arrest, adhesion and extravasation of circulating tumor cells. Developmental Cell, Elsevier, 2018, 45 (1), pp.33-52.e12. ⟨10.1016/j.devcel.2018.02.015⟩. ⟨hal-01694694⟩
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