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Structural insight into the role of the PAS domain for signal transduction in sensor-kinase BvgS

Abstract : The two-component system BvgAS controls the virulence regulon in Bordetella pertussis. BvgS is the prototype of a family of sensor histidine-kinases harboring periplasmic Venus flytrap (VFT) domains. The VFT domains are connected to the cytoplasmic kinase moiety by helical linkers separated by a Per-ARNT-Sim (PAS) domain. Antagonism between the two linkers, as one forms a coiled coil when the other is dynamic and vice versa, regulates BvgS activity. Here we solved the structure of the intervening PAS domain by X-ray
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https://hal.archives-ouvertes.fr/hal-03401949
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Submitted on : Monday, October 25, 2021 - 2:52:27 PM
Last modification on : Tuesday, October 26, 2021 - 4:00:33 AM
Long-term archiving on: : Wednesday, January 26, 2022 - 8:51:26 PM

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  • HAL Id : hal-03401949, version 1

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Elian Dupré, Bernard Clantin, Youhua Yuan, Sophie Lecher, Elodie Lesne, et al.. Structural insight into the role of the PAS domain for signal transduction in sensor-kinase BvgS. Journal of Bacteriology, American Society for Microbiology, 2021. ⟨hal-03401949⟩

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