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Article Dans Une Revue FEBS Journal Année : 2021

The ups and downs of growth hormone secretagogue receptor signaling

María Cornejo
  • Fonction : Auteur
Emilio Mustafá
  • Fonction : Auteur
Daniela Cassano
  • Fonction : Auteur
Jean-Louis Banères
Jesica Raingo
  • Fonction : Auteur
Mario Perello

Résumé

The growth hormone secretagogue receptor (GHSR) has emerged as one of the most fascinating molecules from the perspective of neuroendocrine control. GHSR is mainly expressed in the pituitary and the brain, and plays key roles regulating not only growth hormone secretion but also food intake, adiposity, body weight, glucose homeostasis and other complex functions. Quite atypically, GHSR signaling displays a basal constitutive activity that can be up- or downregulated by two digestive system-derived hormones: the octanoylated-peptide ghrelin and the liver-expressed antimicrobial peptide 2 (LEAP2), which was recently recognized as an endogenous GHSR ligand. The existence of two ligands with contrary actions indicates that GHSR activity can be tightly regulated and that the receptor displays the capability to integrate such opposing inputs in order to provide a balanced intracellular signal. This article provides a summary of the current understanding of the biology of ghrelin, LEAP2 and GHSR and discusses the reconceptualization of the cellular and physiological implications of the ligand-regulated GHSR signaling, based on the latest findings.

Dates et versions

hal-03382633 , version 1 (18-10-2021)

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María Cornejo, Emilio Mustafá, Daniela Cassano, Jean-Louis Banères, Jesica Raingo, et al.. The ups and downs of growth hormone secretagogue receptor signaling. FEBS Journal, 2021, ⟨10.1111/febs.15718⟩. ⟨hal-03382633⟩
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