SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2

Anna Niewiadomska-Cimicka (1) , Frédéric Doussau (2) , Jean-Baptiste Perot (3) , Michel Roux (1) , Celine Keime (1) , Antoine Hache (1) , Françoise Piguet (1) , Ariana Novati (4) , Chantal Weber (1) , Binnaz Yalcin (1) , Hamid Meziane (5) , Marie-France Champy (5) , Erwan Grandgirard (1) , Alice Karam (1) , Nadia Messaddeq (1) , Aurélie Eisenmann (1) , Emmanuel Brouillet (3) , Hoa Huu Phuc Nguyen (4) , Julien Flament (3) , Philippe Isope (2) , Yvon Trottier (1)

1 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
2 INCI - Institut des Neurosciences Cellulaires et Intégratives
3 CEA - Commissariat à l'énergie atomique et aux énergies alternatives
4 Institute of Medical Genetics and Applied Genomics [Tübingen]
5 ICS - Institut Clinique de la Souris

Domaines: Neurobiologie

Anna Niewiadomska-Cimicka, Frédéric Doussau, Jean-Baptiste Perot, Michel Roux, Celine Keime, et al.. SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2. Journal of Neuroscience, 2021, 41 (22), pp.4910-4936. ⟨10.1523/JNEUROSCI.1882-20.2021⟩. ⟨hal-03378998⟩