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Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry

Abstract : Two-dimensional mass spectrometry (2D MS) is a tandem mass spectrometry method that relies on manipulating ion motions to correlate precursor and fragment ion signals. 2D mass spectra are obtained by performing a Fourier transform in both the precursor ion mass-to-charge ratio (m/z) dimension and the fragment ion m/z dimension. The phase of the ion signals evolves linearly in the precursor m/z dimension and quadratically in the fragment m/z dimension. This study demonstrates that phase-corrected absorption mode 2D mass spectrometry improves signal-to-noise ratios by a factor of 2 and resolving power by a factor of 2 in each dimension compared to magnitude mode. Furthermore, phase correction leads to an easier differentiation between ion signals and artefacts, and therefore easier data interpretation.
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Contributor : Marc-André DELSUC Connect in order to contact the contributor
Submitted on : Sunday, October 10, 2021 - 5:03:17 PM
Last modification on : Friday, April 1, 2022 - 3:48:22 AM


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Marc-André Delsuc, Kathrin Breuker, Maria van Agthoven. Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry. Molecules, 2021, 26 (11), pp.3388. ⟨10.3390/molecules26113388⟩. ⟨hal-03372399⟩



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