HLAIb worldwide genetic diversity: new HLA-H alleles and haplotype structure description

Julien Paganini , Laurent Abi-Rached , Philippe Gouret , Pierre Pontarotti (1) , Jacques Chiaroni , Julie Di Cristofaro , France Gemenos , Julie Di Cristofaro

1 MEPHI - Microbes évolution phylogénie et infections

The classical HLA class I genes (HLA Ia) were extensively studied because of their implication in clinical fields and anthropology. Less is known about worldwide genetic diversity and linkage disequilibrium for non-classical HLA class I genes (HLA Ib) and HLA pseudogenes. Notably, HLA-H, which is deleted in a fraction of the population, remains scarcely explored. The aims of this study were 1/ to get further insight into HLA-H genetic diversity and into how this variability potentially affects its expression and 2/ to define HLA Ib worldwide allelic diversity and linkage.

Mots clés: genetic diversity; allele; haplotype; HLA Ib; Next Generation Sequencing Abbreviations: Linkage Disequilibrium: LD; Natural Killer: NK

Domaines: Sciences du Vivant [q-bio]

Julien Paganini, Laurent Abi-Rached, Philippe Gouret, Pierre Pontarotti, Jacques Chiaroni, et al.. HLAIb worldwide genetic diversity: new HLA-H alleles and haplotype structure description. Molecular Immunology, 2019, 112, pp.40-50. ⟨10.1016/j.molimm.2019.04.017⟩. ⟨hal-03371942⟩