Frequency and characteristics of pruritus in patients with monoclonal gammopathy: a case-control study

Cécile Devergne (1) , Hélène Kerspern (2) , F. Poizeau (3) , J.R. Eveillard (1) , J.L. Carré (1) , Laurent Misery (1, 2) , C. Le Gall‐ianotto (2) , E. Brenaut (2)

1 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
2 LIEN - Laboratoire sur les interactions Epithéliums Neurones
3 REPERES - Recherche en Pharmaco-épidémiologie et Recours aux Soins

Chronic pruritus (CP) is a frequent symptom in many skin and systemic diseases(1), including haematological malignancies. It is described in 30% of Hodgkin lymphoma patients and in patients with myeloproliferative disorders, particularly in polycythaemia vera(2,3). Serum protein electrophoresis (SPEP) is recommended in laboratory screening for CP(4). However, the literature about pruritus in monoclonal gammapathies (MGs) is scarce(5-7). The aim of this study was to determine the frequency and clinical characteristics of pruritus in patients with MGs in comparison to controls with normal SPEP results.

Mots clés: Waldenström's macroglobulinemia; pruritus; multiple myeloma; monoclonal gammopathy of undetermined significance; monoclonal gammopathy; itch

Domaines: Sciences du Vivant [q-bio]; Dermatologie; Biologie moléculaire; Hématologie

Cécile Devergne, Hélène Kerspern, F. Poizeau, J.R. Eveillard, J.L. Carré, et al.. Frequency and characteristics of pruritus in patients with monoclonal gammopathy: a case-control study. Journal of the European Academy of Dermatology and Venereology, 2020, 34 (12), ⟨10.1111/jdv.16743⟩. ⟨hal-03370713⟩