Skip to Main content Skip to Navigation
Journal articles

A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria

Abstract : Myxococcus xanthus , a soil bacterium, predates collectively using motility to invade prey colonies. Prey lysis is mostly thought to rely on secreted factors, cocktails of antibiotics and enzymes, and direct contact with Myxococcus cells. In this study, we show that on surfaces the coupling of A-motility and contact-dependent killing is the central predatory mechanism driving effective prey colony invasion and consumption. At the molecular level, contact-dependent killing involves a newly discovered type IV filament-like machinery (Kil) that both promotes motility arrest and prey cell plasmolysis. In this process, Kil proteins assemble at the predator-prey contact site, suggesting that they allow tight contact with prey cells for their intoxication. Kil-like systems form a new class of Tad-like machineries in predatory bacteria, suggesting a conserved function in predator-prey interactions. This study further reveals a novel cell-cell interaction function for bacterial pili-like assemblages.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03365495
Contributor : Julien Herrou Connect in order to contact the contributor
Submitted on : Tuesday, October 5, 2021 - 12:41:51 PM
Last modification on : Friday, November 26, 2021 - 3:08:03 PM

File

elife-72409-v2.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Sofiene Seef, Julien Herrou, Paul de Boissier, Laetitia My, Gael Brasseur, et al.. A Tad-like apparatus is required for contact-dependent prey killing in predatory social bacteria. eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.72409⟩. ⟨hal-03365495⟩

Share

Metrics

Record views

30

Files downloads

48