Staphylococcus aureus Toxins: An Update on Their Pathogenic Properties and Potential Treatments

Nour Ahmad-Mansour (1, 2) , Paul Loubet (3, 4) , Cassandra Pouget (4, 3) , Catherine Dunyach-Remy (3, 4) , Albert Sotto (3, 4) , Jean-Philippe Lavigne (4, 3) , Virginie Molle (1, 2)

1 LPHI - Laboratory of Pathogen Host Interactions [Montpellier]
2 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
3 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
4 VBMI - Virulence bactérienne et maladies infectieuses

Staphylococcus aureus is a clinically important pathogen that causes a wide range of human infections, from minor skin infections to severe tissue infection and sepsis. S. aureus has a high level of antibiotic resistance and is a common cause of infections in hospitals and the community. The rising prevalence of community-acquired methicillin-resistant S. aureus (CA-MRSA), combined with the important severity of S. aureus infections in general, has resulted in the frequent use of anti-staphylococcal antibiotics, leading to increasing resistance rates. Antibiotic-resistant S. aureus continues to be a major health concern, necessitating the development of novel therapeutic strategies. S. aureus uses a wide range of virulence factors, such as toxins, to develop an infection in the host. Recently, anti-virulence treatments that directly or indirectly neutralize S. aureus toxins have showed promise. In this review, we provide an update on toxin pathogenic characteristics, as well as anti-toxin therapeutical strategies.

Mots clés: Staphylococcus aureus; Anti-toxin strategies; Pathogenicity; Toxins; Virulence

Domaines: Bactériologie; Toxicologie

Nour Ahmad-Mansour, Paul Loubet, Cassandra Pouget, Catherine Dunyach-Remy, Albert Sotto, et al.. Staphylococcus aureus Toxins: An Update on Their Pathogenic Properties and Potential Treatments. Toxins, 2021, 13 (10), pp.677. ⟨10.3390/toxins13100677⟩. ⟨hal-03365317⟩