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Article Dans Une Revue International Journal of Molecular Sciences Année : 2021

Staphylococcus aureus Decreases SUMOylation Host Response to Promote Intramacrophage Survival

Résumé

Staphylococcus aureus is a commensal bacterium that causes severe infections in soft tissue and the bloodstream. During infection, S. aureus manipulates host cell response to facilitate its own replication and dissemination. Here, we show that S. aureus significantly decreases the level of SUMOylation, an essential post-translational modification, in infected macrophages 24 h post-phagocytosis. The reduced level of SUMOylation correlates with a decrease in the SUMO-conjugating enzyme Ubc9. The over-expression of SUMO proteins in macrophages impaired bacterial intracellular proliferation and the inhibition of SUMOylation with ML-792 increased it. Together, these findings demonstrated for the first time the role of host SUMOylation response toward S. aureus infection.

Domaines

Bactériologie
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Dates et versions

hal-03365293 , version 1 (05-10-2021)

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Nadhuma Youssouf, Clara Recasens-Zorzo, Virginie Molle, Guillaume Bossis, Philippe Soubeyran, et al.. Staphylococcus aureus Decreases SUMOylation Host Response to Promote Intramacrophage Survival. International Journal of Molecular Sciences, 2021, 22 (15), pp.8108. ⟨10.3390/ijms22158108⟩. ⟨hal-03365293⟩
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