Medica-Plus: A Micromegas-based proof-of-concept detector for sub-becquerel tritium activity assessment at the service of oncological research

F. Jambon (1) , S. Aune (1) , P. Baron (1) , T. Benoit (1) , T. Bey (1) , D. Desforge (1) , E. Ferrer-Ribas (1) , A. Grabas (1) , M. Kebbiri (1) , I. Mandjavidze (1) , T. Papaevangelou (1) , M. Riallot (1) , M. Vandenbroucke (1) , F. Beau (2) , V. Dive (2) , C. Malgorn (2) , F. Malloggi (3) , A. Rousselot (3) , F. Carrel (4) , M. Trocmé (4)

1 IRFU - Institut de Recherches sur les lois Fondamentales de l'Univers
2 SIMoS - Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO)
3 LIONS - Laboratoire Interdisciplinaire sur l'Organisation Nanométrique et Supramoléculaire
4 LCAE (CEA, LIST) - Laboratoire Capteurs et Architectures Electroniques (CEA, LIST)

To fulfil needs in oncological research a new Micromegas detector has been developed to follow radiolabelled drugs in living organisms at the single cell level. This article describes the proof-of-concept of such a detector and compares its ability to detect and assess sub-becquerel ³H activities with a commercial $\beta$-imager.

Mots clés: MPGD; Micromegas; H radiolabelling

Domaines: Instrumentations et Détecteurs [physics.ins-det]

F. Jambon, S. Aune, P. Baron, T. Benoit, T. Bey, et al.. Medica-Plus: A Micromegas-based proof-of-concept detector for sub-becquerel tritium activity assessment at the service of oncological research. Nucl.Instrum.Meth.A, 2022, 1027, pp.166332. ⟨10.1016/j.nima.2022.166332⟩. ⟨hal-03364358⟩