Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter

Christian Billesbølle (1) , Mie Krüger (1) , Lei Shi , Matthias Quick , Zheng Li , Sebastian Stolzenberg , Julie Kniazeff (1) , Kamil Gotfryd (1) , Jonas Mortensen (1) , Jonathan Javitch , Harel Weinstein , Claus Loland (1) , Ulrik Gether (1)

1 Department of Neuroscience and Pharmacology, Panum Institute

Domaines: Biochimie, Biologie Moléculaire; Biologie cellulaire; Biotechnologies; Médecine humaine et pathologie; Neurosciences [q-bio.NC]; Sciences pharmaceutiques

Christian Billesbølle, Mie Krüger, Lei Shi, Matthias Quick, Zheng Li, et al.. Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter:Sodium Symporter. Journal of Biological Chemistry, 2015, 290 (44), pp.26725-26738. ⟨10.1074/jbc.M115.677658⟩. ⟨hal-03363898⟩