Synthesis of Biologically Relevant 1,2,3-and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry

Lori Gonnet (1, 2) , Michel Baron (1) , Michel Baltas (3)

1 RAPSODEE - Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement
2 McGill University = Université McGill [Montréal, Canada]
3 LCC - Laboratoire de chimie de coordination

Green Chemistry has become in the last two decades an increasing part of research interest. Nonconventional «green» sources for chemical reactions include micro-wave, mechanical mixing, visible light and ultrasound. 1,2,3-triazoles have important applications in pharmaceutical chemistry while their 1,2,4 counterparts are developed to a lesser extent. In the review presented here we will focus on synthesis of 1,2,3 and 1,2,4-triazole systems by means of classical and « green chemistry » conditions involving ultrasound chemistry and mechanochemistry. The focus will be on compounds/scaffolds that possess biological/pharmacophoric properties. Finally, we will also present the formal cycloreversion of 1,2,3-triazole compounds under mechanical forces and its potential use in biological systems.

Mots clés: 1 2 3-triazoles; 1 2 4-triazoles; ultrasound; medicinal chemistry; green chemistry; mechanochemistry; biological properties

Domaines: Chimie organique; Chimie thérapeutique

Lori Gonnet, Michel Baron, Michel Baltas. Synthesis of Biologically Relevant 1,2,3-and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry: Review. Molecules, 2021, 26 (18), pp.5667. ⟨10.3390/molecules26185667⟩. ⟨hal-03360993⟩