Aqueous ROPISA of α-amino acid N-carboxyanhydrides: polypeptide block secondary structure controls nanoparticle shape anisotropy

Chloé Grazon (1, 2) , Pedro Salas-Ambrosio (1) , Ségolène Antoine (1) , Emmanuel Ibarboure (1) , Olivier Sandre (1) , Andrew J. Clulow (3, 4) , Ben J. Boyd (4) , Mark Grinstaff (5) , Sébastien Lecommandoux (1) , Colin Bonduelle (1)

1 Team 3 LCPO : Polymer Self-Assembly & Life Sciences
2 ISM - Institut des Sciences Moléculaires
3 Australian Synchrotron [Clayton]
4 MIPS - Monash Institute of Pharmaceutical Sciences [Parkville]
5 BU - Boston University [Boston]

Polymerization-induced self-assembly (PISA) is an efficient one-step process to obtain nanomaterials. In this work, aqueous ring-opening polymerization induced self-assembly (ROPISA) of α-amino acid N-carboxyanhydride (NCA) affords controllable well-defined nanoassemblies. ROPISA with the PEG5 kDa-NH2 macroinitiator and either the benzyl-L-glutamate NCA (BLGNCA) or L-leucine NCA (LeuNCA) monomer yields amphiphilic block copolymers, with different polypeptide molar masses, which spontaneously form nanostructures. In contrast to the previous PISA process where the hydrophobic to hydrophilic ratio was the main parameter defining nanomaterial morphology, the secondary structure of the polypeptides is the main driving force to stabilize the anisotropic rod-like nanostructures with this ROPISA process.

Domaines: Polymères

Chloé Grazon, Pedro Salas-Ambrosio, Ségolène Antoine, Emmanuel Ibarboure, Olivier Sandre, et al.. Aqueous ROPISA of α-amino acid N-carboxyanhydrides: polypeptide block secondary structure controls nanoparticle shape anisotropy. Polymer Chemistry, 2021, 12 (43), pp.6242-6251. ⟨10.1039/D1PY00995H⟩. ⟨hal-03359087⟩